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In order to make the PowerPoint loop play works efficiently, remember to set the animations, transitions and timings well in advance.
With an easy setting we can make the PowerPoint loop play:
(For all PowerPoint versions, the setting is the same)
1. Click "Slide Show" on the ribbon, and choose "Set Up Slide Show" in the "Set Up" section.
2. In the pop up "Set Up Show" window, check the box for "Loop continuously until 'Esc'".